Ion Channels and Migraine

Investigating Meningeal Ion Channels as New Molecular Targets for Migraine

As members of the Dissertation Committee, we certify that we have read the dissertation prepared by Xiaomei Wei entitled " Investigating meningeal ion channels as new molecular targets for migraine " and recommend that it be accepted as fulfilling the dissertation requirement for the Degree of Doctor of Philosophy Final approval and acceptance of this dissertation is contingent upon the candida...

O 13: Ion Channels in Autoimmune Neurodegeneration

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only parti...

o 13: ion channels in autoimmune neurodegeneration

multiple sclerosis (ms) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. ionic conductances regulate t cell activation as well as neuronal function and thus have been found to play a crucial role in ms pathogenesis. since present therapeutical approaches are only parti...

Receptors and ion channels.

Ion channels and epilepsy

Ion channels play a central role in the generation and control of neuronal excitability. Genetic defects in ion channels are associated with several forms of human idiopathic epilepsies. These defects range from nonsense and missense point mutations to insertion, truncation and splice site mutations producing altered, non-functional or negative-dominant channel subunits. To date, 12 mutated gen...